| Exit 1A | West Beach | 0.4 mi |
| Exit 1C | Teichman Road;Harborside Drive | 1.8 mi |
| Exit 1B | 71st Street | 1.6 mi |
| Exit 8 | | 1.2 mi |
| Exit 10 | Main Street | right at the exit |
| Exit 11 | | 1.5 mi |
| Exit 12 | | 1.6 mi |
| Exit 13 | | 1.8 mi |
| Exit 15 | | right at the exit |
| Exit 16 | Texas City | 0.8 mi |
| Exit 17 | Tanger Outlet Center | 1.5 mi |
| Exit 20 | Santa Fe | 0.5 mi |
| Exit 22 | League City Parkway | right at the exit |
| Exit 23 | League City | right at the exit |
| Exit 24 | NASA | 1.5 mi |
| Exit 27 | El Dorado Boulevard | 1.0 mi |
| Exit 28 | El Dorado Boulevard | 1.1 mi |
| Exit 29 | Friendswood;Clear Lake City Boulevard | 1.2 mi |
| Exit 30 | Ellington Airport;Dixie Farm Road | 0.3 mi |
| Exit 31 | Frontage Road;Scarsdale Boulevard | 0.8 mi |
| Exit 32 | Sam Houston Tollway | 0.7 mi |
| Exit 33 | Fuqua Street | 0.5 mi |
| Exit 34 | South Shaver Road;Almeda-Genoa Road | 1.1 mi |
| Exit 35 | Edgebrook Drive;Clearwood Drive | right at the exit |
| Exit 36 | Hobby Airport | right at the exit |
| Exit 38 | Howard Drive;Hobby Airport;Monroe Road;Bellfort Avenue | 0.3 mi |
| Exit 38B | Howard Drive;Bellfort Avenue | right at the exit |
| Exit 39 | Park Place Boulevard;Broadway Boulevard | right at the exit |
| Exit 40A | Frontage Road | 0.6 mi |
| Exit 40B | Pasadena | 0.4 mi |
| Exit 40C | Pearland;Alvin | 0.4 mi |
| Exit 41A | Woodbridge Drive | right at the exit |
| Exit 41B | South Wayside Drive;Old Spanish Trail;Griggs Road;Broad Street | 1.3 mi |
| Exit 44C | Cullen Boulevard;Lockwood-Elgin | right at the exit |
| Exit 45 | Lake Jackson;Freeport;Cleveland;Victoria;Texas Southern University | 0.8 mi |
| Exit 46A | Cleveland | right at the exit |
| Exit 46B | Lake Jackson;Freeport;Victoria | 1.0 mi |
| Exit 47A | Allen Parkway | 1.1 mi |
| Exit 47B | Houston Avenue;Memorial Drive | 1.1 mi |
| Exit 48A | Beaumont | 1.2 mi |
| Exit 48B | San Antonio | 1.4 mi |
| Exit 49B | North Main Street;Houston Avenue | 0.8 mi |
| Exit 50 | Cavalcade Street;Patton Street | 0.8 mi |
| Exit 50A | Patton Street | 0.7 mi |
| Exit 50B | Cavalcade Street;Link Road | right at the exit |
| Exit 51 | | 0.8 mi |
| Exit 52A | Frontage Road | 1.5 mi |
| Exit 52B | Crosstimbers Road | right at the exit |
| Exit 53 | Airline Drive | right at the exit |
| Exit 55A | Parker Road;Yale Street | right at the exit |
| Exit 55B | Little York Road | 0.3 mi |
| Exit 56A | Shepherd Drive | 0.6 mi |
| Exit 56B | Little York Road;Veterans Memorial Drive | 1.3 mi |
| Exit 57A | Gulf Bank Road | 1.1 mi |
| Exit 57B | West Mount Houston Road | 0.4 mi |
| Exit 59 | West Road | right at the exit |
| Exit 60A | Aldine Bender Road;Fallbrook Road | right at the exit |
| Exit 60D | George Bush Intercontinental Airport | right at the exit |
| Exit 60B | Bush Intercontinental Airport;Sam Houston Tollway West | 0.6 mi |
| Exit 60C | Sam Houston Tollway | right at the exit |
| Exit 61 | Greens Road | right at the exit |
| Exit 62 | Rankin Road;Kuykendahl Road | right at the exit |
| Exit 63 | Airtex Drive | 0.3 mi |
| Exit 66B | Hollow Tree Street;Parramatta Lane | 0.4 mi |
| Exit 68 | Cypresswood Drive;Holzwarth Road | 0.4 mi |
| Exit 70A | Tomball | 0.5 mi |
| Exit 70B | Spring Stuebner Road West | 0.5 mi |
| Exit 71A | Grand Parkway | 1.6 mi |
| Exit 72 | Hardy Toll Road South;Springwoods Village Parkway | 0.9 mi |
| Exit 72B | Hardy Toll Road South | 1.1 mi |
| Exit 73 | Rayford Road;Sawdust Road | right at the exit |
| Exit 76 | Robinson Road;Woodlands Parkway | 0.5 mi |
| Exit 76A | Robinson Road | 0.3 mi |
| Exit 76B | Woodlands Parkway | 0.7 mi |
| Exit 77 | Lake Woodlands Drive;Research Forest Drive;Tamina Road | 0.5 mi |
| Exit 79 | Lone Star College Montgomery;Sam Houston State University;Woodloch | 0.8 mi |
| Exit 79A | College Park Drive;Needham Road | 0.8 mi |
| Exit 79B | | 0.7 mi |
| Exit 83 | Crighton Road;Grand Central Parkway | 1.1 mi |
| Exit 84 | Frazier Street | 0.6 mi |
| Exit 84B | Frazier Street | 0.9 mi |
| Exit 85 | Gladstell Street | 0.5 mi |
| Exit 87A | Conroe | 0.3 mi |
| Exit 90 | League Line Road | 0.6 mi |
| Exit 95 | Longstreet Road | 1.5 mi |
| Exit 102 | New Waverly | 0.8 mi |
| Exit 103 | | 1.3 mi |
| Exit 112 | Veterans Memorial Parkway | 0.3 mi |
| Exit 113 | Riverside;Crockett;Grapeland | 0.9 mi |
| Exit 114 | Montgomery Road | 0.8 mi |
| Exit 115 | Avenue S;Montgomery Road | 0.7 mi |
| Exit 116 | 11th Street | 1.1 mi |
| Exit 117 | Crosstimbers Drive;Eastham Lane | 1.1 mi |
| Exit 118 | Sam Houston State University | right at the exit |
| Exit 142 | Bryan;Crockett | right at the exit |
| Exit 152 | Normangee | right at the exit |
| Exit 164 | Centerville | right at the exit |
| Exit 178 | Buffalo;Jewett | 0.7 mi |
| Exit 180 | Groesbeck | 1.2 mi |
| Exit 189 | Teague | right at the exit |
| Exit 197 | Fairfield;Teague | 0.4 mi |
| Exit 198 | Fairfield;Wortham | 0.3 mi |
| Exit 218 | Richland | 0.8 mi |
| Exit 219A | Wortham;Groesbeck | 0.5 mi |
| Exit 219B | Frontage Road | 0.7 mi |
| Exit 220 | Frontage Road | 1.3 mi |
| Exit 227 | Athens;Waco | 0.6 mi |
| Exit 228A | 15th Street | 1.1 mi |
| Exit 228B | Corsicana | 0.7 mi |
| Exit 229 | Palestine | right at the exit |
| Exit 231 | Waco;Athens | right at the exit |
| Exit 242 | Calhoun Street | 0.3 mi |
| Exit 243 | Frontage Road | 1.1 mi |
| Exit 251A | Creechville Road | 1.7 mi |
| Exit 251B | Kaufman;Italy | 1.6 mi |
| Exit 253 | Ennis | right at the exit |
| Exit 255 | Garrett | 1.3 mi |
| Exit 258 | Palmer | 2.0 mi |
| Exit 259 | Jefferson Street | 1.0 mi |
| Exit 260 | Frontage Road | 0.3 mi |
| Exit 264 | Frontage Road | 0.8 mi |
| Exit 265 | | 1.8 mi |
| Exit 266 | 5th Street | 0.6 mi |
| Exit 267 | Frontage Road | 1.0 mi |
| Exit 269 | Mars Road | 1.0 mi |
| Exit 270 | Belt Line Road | right at the exit |
| Exit 271 | Pleasant Run Road | 1.3 mi |
| Exit 272 | Fulghum Road | 1.9 mi |
| Exit 273 | Wintergreen Road | 1.3 mi |
| Exit 274 | Dowdy Ferry Road;Palestine Street | right at the exit |
| Exit 275 | | 0.8 mi |
| Exit 276A | Fort Worth | 1.3 mi |
| Exit 276B | Shreveport | 1.4 mi |
| Exit 279 | | right at the exit |
| Exit 280 | Linfield Street;Illinois Avenue | right at the exit |
| Exit 281 | Overton Road | 1.0 mi |
| Exit 282 | | 1.8 mi |
| Exit 283A | Lamar Street | 1.8 mi |
| Exit 283B | Fair Park;SM Wright Freeway;Martin Luther King Jr. Boulevard | 1.0 mi |
| Exit 284A | | 1.1 mi |
| Exit 284C | Downtown;Good–Latimer Expressway | 0.7 mi |
| Exit 284B | Live Oak Street | 0.7 mi |