| Exit 1A | West Beach | 1.0 mi |
| Exit 13 | | 1.4 mi |
| Exit 15 | | 0.7 mi |
| Exit 16 | Texas City | 1.4 mi |
| Exit 24 | NASA | 1.9 mi |
| Exit 26 | University of Houston-Clear Lake | 2.0 mi |
| Exit 27 | El Dorado Boulevard | 1.9 mi |
| Exit 28 | El Dorado Boulevard | 1.1 mi |
| Exit 29 | Friendswood;Clear Lake City Boulevard | 1.3 mi |
| Exit 31 | Frontage Road;Scarsdale Boulevard | 1.4 mi |
| Exit 32 | Sam Houston Tollway | 1.2 mi |
| Exit 33 | Fuqua Street | 1.2 mi |
| Exit 34 | South Shaver Road;Almeda-Genoa Road | 1.1 mi |
| Exit 35 | Edgebrook Drive;Clearwood Drive | right at the exit |
| Exit 36 | Hobby Airport | 0.3 mi |
| Exit 38 | Howard Drive;Hobby Airport;Monroe Road;Bellfort Avenue | 1.0 mi |
| Exit 40A | Frontage Road | 0.9 mi |
| Exit 41A | Woodbridge Drive | 0.4 mi |
| Exit 41B | South Wayside Drive;Old Spanish Trail;Griggs Road;Broad Street | 1.2 mi |
| Exit 42 | South Wayside Drive | 0.3 mi |
| Exit 43A | Telephone Road | 0.5 mi |
| Exit 43B | Tellepsen Street | 0.5 mi |
| Exit 44A | Elgin Street;Lockwood Drive;Cullen Boulevard | 1.2 mi |
| Exit 44B | | 0.6 mi |
| Exit 44C | Cullen Boulevard;Lockwood-Elgin | 0.5 mi |
| Exit 45 | Lake Jackson;Freeport;Cleveland;Victoria;Texas Southern University | 0.9 mi |
| Exit 45A | Scott Street | right at the exit |
| Exit 46 | St Joseph Parkway;Pease Street;Emancipation Avenue | 0.5 mi |
| Exit 46A | Cleveland | 0.7 mi |
| Exit 46B | Lake Jackson;Freeport;Victoria | 1.4 mi |
| Exit 47A | Allen Parkway | 0.8 mi |
| Exit 47D | I-45 South;Express Lane;Dallas Street;Pierce Street | 0.8 mi |
| Exit 47B | Houston Avenue;Memorial Drive | 0.6 mi |
| Exit 47C | McKinney Street | 0.8 mi |
| Exit 48A | Beaumont | 0.6 mi |
| Exit 48B | San Antonio | 0.3 mi |
| Exit 49A | Quitman Street | 0.5 mi |
| Exit 49B | North Main Street;Houston Avenue | 0.3 mi |
| Exit 50 | Cavalcade Street;Patton Street | 0.6 mi |
| Exit 50A | Patton Street | right at the exit |
| Exit 50B | Cavalcade Street;Link Road | 0.4 mi |
| Exit 51 | | 0.8 mi |
| Exit 52A | Frontage Road | 0.9 mi |
| Exit 52B | Crosstimbers Road | 0.8 mi |
| Exit 53 | Airline Drive | right at the exit |
| Exit 54 | Tidwell Road | 0.7 mi |
| Exit 55A | Parker Road;Yale Street | right at the exit |
| Exit 55B | Little York Road | 0.6 mi |
| Exit 57B | West Mount Houston Road | 0.9 mi |
| Exit 59 | West Road | 1.4 mi |
| Exit 60A | Aldine Bender Road;Fallbrook Road | 0.5 mi |
| Exit 60D | George Bush Intercontinental Airport | 0.3 mi |
| Exit 60B | Bush Intercontinental Airport;Sam Houston Tollway West | 0.4 mi |
| Exit 60C | Sam Houston Tollway | 0.3 mi |
| Exit 61 | Greens Road | 1.1 mi |
| Exit 62 | Rankin Road;Kuykendahl Road | 1.2 mi |
| Exit 63 | Airtex Drive | 0.8 mi |
| Exit 66 | Addicks;Humble | 0.8 mi |
| Exit 66B | Hollow Tree Street;Parramatta Lane | 0.9 mi |
| Exit 68 | Cypresswood Drive;Holzwarth Road | 0.7 mi |
| Exit 70A | Tomball | 0.7 mi |
| Exit 70B | Spring Stuebner Road West | 0.8 mi |
| Exit 72 | Hardy Toll Road South;Springwoods Village Parkway | 1.8 mi |
| Exit 76 | Robinson Road;Woodlands Parkway | right at the exit |
| Exit 76B | Woodlands Parkway | 0.7 mi |
| Exit 79 | Lone Star College Montgomery;Sam Houston State University;Woodloch | 0.8 mi |
| Exit 81 | Magnolia;Hempstead | 0.3 mi |
| Exit 82 | River Plantation Drive | 0.6 mi |
| Exit 83 | Crighton Road;Grand Central Parkway | 1.1 mi |
| Exit 84 | Frazier Street | 0.9 mi |
| Exit 84B | Frazier Street | 0.9 mi |
| Exit 85 | Gladstell Street | 1.0 mi |
| Exit 87 | Conroe | 0.6 mi |
| Exit 87A | Conroe | 1.2 mi |
| Exit 87B | Wilson Road | 0.6 mi |
| Exit 89 | Teas Nursery Road | 1.2 mi |
| Exit 90 | League Line Road | 0.3 mi |
| Exit 92 | Seven Coves Road | 1.9 mi |
| Exit 103 | | right at the exit |
| Exit 115 | Avenue S;Montgomery Road | 0.7 mi |
| Exit 116 | 11th Street | right at the exit |
| Exit 117 | Crosstimbers Drive;Eastham Lane | 1.8 mi |
| Exit 164 | Centerville | right at the exit |
| Exit 178 | Buffalo;Jewett | 0.3 mi |
| Exit 197 | Fairfield;Teague | right at the exit |
| Exit 228B | Corsicana | 1.9 mi |
| Exit 229 | Palestine | 1.8 mi |
| Exit 231 | Waco;Athens | right at the exit |
| Exit 232 | Roane Road | 1.2 mi |
| Exit 251A | Creechville Road | 0.7 mi |
| Exit 251B | Kaufman;Italy | right at the exit |
| Exit 253 | Ennis | 1.9 mi |
| Exit 255 | Garrett | right at the exit |
| Exit 258 | Palmer | right at the exit |
| Exit 270 | Belt Line Road | right at the exit |
| Exit 277 | Paul Quinn College | 1.8 mi |
| Exit 279 | | 0.9 mi |
| Exit 279A | | 1.2 mi |
| Exit 279B | | 1.2 mi |
| Exit 280 | Linfield Street;Illinois Avenue | 0.9 mi |
| Exit 281 | Overton Road | 0.3 mi |
| Exit 284C | Downtown;Good–Latimer Expressway | 1.0 mi |